Wednesday, June 11, 2014

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Tramadol hydrochloride is an orally active, centrally acting analgesic with a dual mechanism of action introduced in July 1994. It has been used in post-surgical pain, obstetric pain, and chronic pain of mechanical and neurogenic origin. Analgesic tolerance is not a significant problem, and psychological dependence and euphoric effects are minimal.

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Tramadol, the generic version of Ultram, is a centrally acting opioid analgesic. The exact mode of action of tramadol is unknown but it is said to work like morphine. Tramadol has dual mechanism of action. The results of clinical studies suggest that tramadol-induced antinociception is mediated by opioid (µ, mu) and non-opioid (inhibition of re-uptake of norepinephrine and serotonin) mechanisms. There is evidence that, in tramadol, both mechanisms act synergistically with respect to analgesia.

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